"Differential Responses to Challenge with Live and Dead Mycobacterium bovis Bacillus Calmette-Guerin."

According to the authors' abstract of an article published in Journal of Immunology, "Bacillus Calmette-Guerin (BCG) vaccination has been shown to protect against challenge with virulent Mycobacterium tuberculosis in a range of experimental animal models: in each case, protective efficacy requires vaccination with live bacteria. With the goal of moving to a new generation of safer, nonliving vaccines, efforts have been made to identify the factors that determine the efficacy of live vaccination. We show that injection of live, but not dead, BCG induces localized swelling in the mouse footpad model. Live and dead bacteria induce similar responses during the first week after...

Want to see the full article?

• Purchase this article for only $3.00