"Rhesus Macaques Previously Infected with Simian/Human Immunodeficiency Virus Are Protected from Vaginal Challenge with Pathogenic SIVmac239."

According to the authors' abstract of an article published in Journal of Virology, "Nontraumatic vaginal inoculation of rhesus macaques with a simian/human immunodeficiency virus (SIV/ HIV) chimera containing the envelope gene from HIV-1 89.6 (SHIV 89.6) results in systemic infection (Y. Lu, B. Brosio, M. Lafaile, J. Li, R.G. Collman, J. Sodroski, and C. J, Miller, J. Virol. 70:3045-3050, 1996). A total of five rhesus macaques have each been infected by exposure to at least three intravaginal inoculations of SHIV 89.6. The SHIV 89.6 infection is characterized by a transient viremia that evokes humoral and cellular immune responses to HIV and SIV antigens, but disease does not develop in...

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