Plasmodium berghei (Animal Models)

Immunization Induced Rapid Onset of Vaccine-Induced Death

Published in Vaccine Weekly, March 31st, 1997

A unique model to characterize immune responses to malaria that are deleterious to the host may lead to the development of a blocker of those responses.

R.C. Reed, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, and colleagues investigated whether lipopeptide derivatized circumsporozoite (CS) protein B and T helper epitopes in various combinations induce protective immune responses against sporozoite challenge ("Rapid Onset of Malaria-Induced Mortality by Immunizations with Lipo-Peptides: An Experimental Model to Study Deleterious Immune Responses and Immunopathology in Malaria," Vaccine, 1997;15:65-70).

Protective immune...

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Source: Vaccine Weekly (1997-03-31)

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