"Anti-HVR1 Antibody is Cross-Reactive to Unrelated HCV in Virus Capture and Peptide ELISA."

According to an abstract submitted by the authors to the 4th International Meeting on Hepatitis C Virus and Related Viruses, Molecular Virology and Pathogenesis, held March 6-10, 1997, in Kyoto, Japan, "In order to investigate the cross-reactivity of antihypervariable region 1 (HVR1) antibody (Ab) against hepatitis C virus (HCV) in HCV infection, we prepared mouse anti-HVR1 Ab against HCV#6 isolate (anti-#6 Ab), and examined it for the cross-reactivity to other HCV isolates. The anti-#6 Ab captured the free particle of HCV No7 in vitro and bound to HVR1 peptide of No7 in ELISA, in spite of only 58.1% homology of HVR1 sequence between the two isolates. To determine the general frequency...

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