HIV Vaccines

B-Cell Superantigen Found on HIV Envelope

Published in Vaccine Weekly, April 14th, 1997

A new finding may revive efforts to develop HIV vaccines based on the viral envelope.

Previously, it was shown that HIV-1 acts as a superantigen for normal B lymphocytes, inducing abnormally widespread activation by crosslinking membrane IgM.

"This superantigen-like property is thought to be responsible for the increase in V_H 3+ B cells during early stages of the infection followed by their progressive decline during advanced stages of the disease," noted Saoussen Karray and Moncef Zouali of the Pasteur Institute, Paris France.

In a paper published in the Proceedings of the National Academy of Sciences, Karray and...

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Source: Vaccine Weekly (1997-04-14)

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