"Adoptive Immunotherapy as an in vivo Model to Explore Antitumor Mechanisms Induced by a Recombinant Anticancer Vaccine."

According to the authors' abstract of an article published in Journal of Immunotherapy, "We have described previously the construction, generation, and in vivo biologic consequences of a recombinant vaccinia virus containing the human CEA gene (rV-CEA) in an experimental murine colon carcinoma model. Immunization of C57BL/6 mice with rV-CEA led to antigen-specific inhibition of tumor growth in both prophylactic and therapeutic settings. Although such antitumor effects were correlated with the induction of CEA-specific T-cell responses, their exact contribution in the tumor rejection mechanism remained unclear. In this study, we examined the mechanism of action of rV-CEA, with emphasis...

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