Intracellular Immunization
Chimera Attacks HIV From Within
Published in Vaccine Weekly, April 21st, 1997
The gift horse in this case is a genetically engineered HIV protein that the growing virus welcomes inside its gate and incorporates into new virus particles. Once inside, the decoy protein uses up so much of the viral protease that there is not enough left over to make new infectious virions.
"We have shown that a novel class of HIV-1 agents can be generated with the desirable end result of eliminating virus infection," wrote D. Serio of Thomas Jefferson University, Philadelphia, Pennsylvania, and colleagues. "This class of agents, which we have termed 'anti-HIV agents...
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Source: Vaccine Weekly (1997-04-21)
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