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Vaccine Development (Human Papillomavirus)

Global HPV-16 Study Breaks Ground for Vaccine Design

Published in Vaccine Weekly, April 21st, 1997

A new study charts the worldwide distribution of human papillomavirus type 16 (HPV-16) variants, laying the groundwork for future efforts to develop a vaccine.

HPV DNA can be detected in 93 percent of invasive cervical cancers; about half of these are due to HPV-16 (The International Biological Study of Cervical Cancer [IBSCC], Bosch et al., J Natl Cancer Inst, 1995;87:796-802).

HPV-16 vaccines are already in development, but researchers are hampered by lack of knowledge about the virus. The disease risk of subtype variants remains unknown, and few variants other than the European subtype have been studied at all. No one has yet shown whether...

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