Published in Vaccine Weekly, May 12th, 1997
Induction of oral tolerance has long been proposed as a means of treating or preventing allergic and autoimmune diseases. But traditional approaches require feeding of massive doses of antigen over a long period, and these approaches generally fail in individuals who already are immunologically sensitized.
Previous studies demonstrated that microgram amounts of antigen coupled with CTB can suppress systemic T-cell-mediated inflammatory responses in both naive and immune animals (Sun et al., PNAS, 1994;91:10795-9).
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