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HAV Vaccines

"Virosomal Hepatitis A Vaccine (Strain RG-SB): A Preliminary Review of Its Immunogenicity, Protective Efficacy and Tolerability in At-Risk Populations."

Published in Vaccine Weekly, June 9th, 1997

According to the authors' abstract of an article published in Biodrugs, "Virosomal hepatitis A vaccine contains formalin-inactivated hepatitis A (strain RG-SB) antigen adsorbed on to immunopotentiating reconstituted influenza virosomes (IRIVs). IRIVs act as an adjuvant and may stimulate both the cell-mediated and humoral immune responses to vaccine antigens. In noncomparative studies, virosomal hepatitis A vaccine (500 radioimmunoassay units) has exhibited immunogenicity in adults and children, inducing seroconversion in almost all volunteers within 4 weeks (usually within 2 weeks) of vaccination. Booster injections of the virosomal vaccine 12 months after the initial dose increased...

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