"The Problem of Multiplicity in Malaria Vaccine Development."

According to the author's abstract of an article published in Annals of Tropical Medicine and Parasitology, "Vaccine development in the field of malaria is probably most severely hampered by the multiplicity of the factors involved: multiple hosts; multiple stages of the life-cycle; multiple antigens per stage; multiple epitopes per antigen; multiple alleles of some antigens; multiple forms of the same antigen; multiple arms of the immune system; multiple immune responses in different hosts; multiple species of the parasite; and multiple forms of the disease in different settings. As a result, there are other, practical obstacles, such as multiple claims on ownership of antigens and...

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