HIV Vaccines
"Protection of Monkeys Vaccinated with vpr- and/or nef-Defective Simian Immunodeficiency Virus Strain Mac Human Immunodeficiency Virus Type 1 Chimeric Viruses: A Potential Candidate Live-Attenu
Published in Vaccine Weekly, June 23rd, 1997
According to the authors' abstract of an article published in Journal of General Virology, "Two simian immunodeficiency virus strain mac (SIVmac)/human immunodeficiency virus type 1 (HIV-1) chimeric viruses (SHIVs), designated NM-3 and NM-3n, with env derived from HIV-1 and defective vpr (plus defective nef for NM-3), were inoculated into seven macaques. These macaques were transiently or persistently infected and most of them produced long-lasting neutralizing antibodies and Env-specific killer T cells to HIV-1 with no AIDS-like symptoms. When they were challenged with another SHIV with intact vpr and nef (designated NM-3rN), all were protected as judged by virus recovery, DNA detection...
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Source: Vaccine Weekly (1997-06-23)
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