Malaria Vaccines
"Multi-Gene Vaccination Against Malaria: A Multistage, Multi-Immune Response Approach."
Published in Vaccine Weekly, June 30th, 1997
According to the authors' abstract of an article published in Parasitology Today, "An ideal malaria vaccine will induce immune responses against each stage of the Plasmodium spp life cycle. During its complicated life cycle, the parasite exists extracellularly in the host's bloodstream, within cells that express major histocompatibility complex (MHC) molecules (hepatocytes), within cells that do not express MHC molecules (erythrocytes) and within the mosquito vector. Different arms of the immune system are required to attack the parasite at the different stages. Therefore, a multistage vaccine must be a multi-immune response vaccine. In addition, given the unique antigenicities...
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Source: Vaccine Weekly (1997-06-30)
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