"Mathematical Model of the Trafficking of Acid-Dependent Enveloped Viruses: Application to the Binding, Uptake, and Nuclear Accumulation of Baculovirus."

According to the authors' abstract of an article published in Biotechnology and Bioengineering, "A quantitative understanding of virus trafficking would be useful in treating viral-mediated diseases, developing protocols for viral gene therapy, designing infection regimens for viral expression systems, and optimizing vaccine and recombinant protein production. Here, we present a mathematical model of the attachment, internalization, endosomal fusion, lysosomal routing, and nuclear accumulation of baculovirus in SF21 insect cells. The model accounts for multivalent bond formation of the virus with cell surface receptors. The model mimics accurately the experimental trafficking dynamics...

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