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Immunology

FLT3 Ligand Increases Dendritic Cells That Boost Immune System Response

Published in Vaccine Weekly, July 7th, 1997

Immunex Corp., Seattle, Washington, presented results of a Phase I human clinical study demonstrating that Flt3 ligand can induce large numbers of dendritic cells.

Dendritic cells are a type of immune system cell that plays a key role in initiating an immune response to cancer and infectious diseases.

The study data, presented at the 13th European Immunology Meeting, held in Amsterdam, The Netherlands, during June 1997, showed an average 30-fold increase in functionally mature dendritic cells (DC) in the peripheral blood of subjects treated with Flt3 ligand. The increase in DC was detected as early as day 5 of treatment, peaking by day 9 to an...

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