Published in Vaccine Weekly, July 7th, 1997
The "tap and drain" model first proposed by David Ho holds that CD4+ T-cell levels are maintained by a dynamic balance between the "tap" pouring in new activated T cells and the "drain" of cell death. HIV acts to widen the drain so that even with the tap wide open, T-cell levels gradually decline to zero.
The model is so deeply entrenched among researchers that "tap-and-drain" cartoons are a common feature of slide presentations at scientific meetings. But the model is profoundly...
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