Conference Coverage (SPIRAT/NCDDG-HIV)

T-Cell Homeostasis Seen As Key to Immune Regeneration

Published in Vaccine Weekly, July 7th, 1997

A different way of looking at T cells challenges an accepted model of HIV disease and suggests that curing HIV disease will involve more than killing the virus.

The "tap and drain" model first proposed by David Ho holds that CD4⁺ T-cell levels are maintained by a dynamic balance between the "tap" pouring in new activated T cells and the "drain" of cell death. HIV acts to widen the drain so that even with the tap wide open, T-cell levels gradually decline to zero.

The model is so deeply entrenched among researchers that "tap-and-drain" cartoons are a common feature of slide presentations at scientific meetings. But the model is profoundly...

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Source: Vaccine Weekly (1997-07-07)

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