"Antitumor Effects of Nonconjugated Murine Lym-2 and Human-Mouse Chimeric CLL-1 Monoclonal Antibodies Against Various Human Lymphomas."

According to an abstract submitted by the authors to the 88th Annual Meeting of the American Association for Cancer Research, held April 12-16, 1997, in San Diego, California, "Lym-2 is a murine monoclonal antibody (moAb) reactive with both normal and neoplastic human lymphocytes directed towards a human class II molecule variant. Previous studies have demonstrated that signals transmitted by class II molecules which stimulate normal lymphocytes can be inhibitory for B-cell lymphoma growth by inducing activation-induced cell death. We evaluated the effects of nonconjugated murine Lym-2 on the growth of various human lymphomas using both in vitro and in vivo assays. A human-mouse...

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