Testing (TB)

Whole Blood IFN-gamma Better than TST for Assessing Reactivity

Published in Vaccine Weekly, July 28th, 1997

Tuberculin reactivity appears to be more detectable by the whole blood interferon-gamma assay than by tuberculin skin testing, according to a report from Baltimore, Maryland's Johns Hopkins University.

A whole blood assay for the diagnosis of bovine TB recently was developed that overcame many of the shortcomings associated with tuberculin skin test (TST). The assay is based on the incubation of whole blood with purified protein derivative and the subsequent measurement of interferon (IFN)-gamma released from PPD-reactive T cells in infected animals.

The assay system was highly sensitive and specific for the detection of Mycobacterium bovis...

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Source: Vaccine Weekly (1997-07-28)

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