"Gene Therapy of Metastatic Animal and Human Cancers."

According to an abstract submitted by authors to the Keystone Symposium Cellular Immunology and the Immunotherapy of Cancer - III, held February 1-7, 1997, in Copper Mountain, Colorado, "The local production of human cytokines in the tumor site by virus vectors, engineered tumor cells or xenogeneic cells has been shown in various murine models to promote a strong immune response leading to tumor growth inhibition or rejection. However, these observations have been limited by the artificial nature of the animal model: implantation into syngeneic hosts of mouse tumor cell lines only imperfectly mimics the biology of spontaneous human cancers. To assess whether such gene therapy vectors...

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