Published in Vaccine Weekly, August 18th, 1997
Researchers Edward T. Ryan and colleagues of Massachusetts General Hospital and Harvard University created a fusion protein incorporating the nontoxic portion of C. difficile toxin A. They successfully introduced a plasmid encoding the protein into a live, attenuated strain of Vibrio cholera which they then inoculated orally into rabbits.
"A V. cholera vector strain secreting a nontoxic, immunogenic portion of C. difficile toxin A fused to the secretion signal of...
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