Clostridium Vaccines

V. Cholerae Vector Carries Clostridium Antigen, Elicits Immunity

Published in Vaccine Weekly, August 18th, 1997

A genetically engineered, live, attenuated cholera strain induced mucosal and systemic immunity to Clostridium difficile toxin in animal studies.

Researchers Edward T. Ryan and colleagues of Massachusetts General Hospital and Harvard University created a fusion protein incorporating the nontoxic portion of C. difficile toxin A. They successfully introduced a plasmid encoding the protein into a live, attenuated strain of Vibrio cholera which they then inoculated orally into rabbits.

"A V. cholera vector strain secreting a nontoxic, immunogenic portion of C. difficile toxin A fused to the secretion signal of...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Vaccine Weekly

Source: Vaccine Weekly (1997-08-18)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry