Autoimmune Disease

Immunization Protects Against Multiple Autoimmune Diseases

Published in Vaccine Weekly, September 1st, 1997

Immunization of mice with a single T-cell-receptor (TCR) antagonist peptide protected them against several different types of autoimmune disease.

The finding has major implications for the treatment of multiple sclerosis and other demyelinating diseases.

"Clearly, if protective immunization can be established with a single TCR antagonist peptide which itself is nonpathogenic, antagonizes specific pathogenic Th1 cells, and induces regulatory T cells, it may provide a desirable therapeutic option for use in the treatment of many autoimmune diseases," wrote Lindsay B. Nicholson and colleagues of Brigham and Women's Hospital and Harvard Medical School,...

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Source: Vaccine Weekly (1997-09-01)

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