Immunology (HBV)

Vaccination Against Hepatitis B May Select Mutant Virus

Published in Vaccine Weekly, September 1st, 1997

Immune pressure exerted by vaccination against hepatitis B at birth may select for a mutant virus in those that become carriers, according to a report from Taiwan.

Researcher Ping-Ing Lee and colleagues suggested that incorporation of hepatitis B surface antigen (HBsAg) corresponding to individual variants could solve the problem of mutation ("Detection of Hepatitis B Surface Gene Mutation in Carrier Children with or without Immunoprophylaxis at Birth," Journal of Infectious Diseases, 1997;176:427-430).

Infants born to hepatitis B e antigen (HBeAg)-positive carrier mothers are prone to contract hepatitis B virus (HBV) infection at birth, and...

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Source: Vaccine Weekly (1997-09-01)

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