Cancer Vaccines
"Lack of Correlation Between Rejection of Tumor Cells Co-Expressing Interleukin-2 and B7.1 and Vaccine Efficiency."
Published in Vaccine Weekly, September 8th, 1997
According to the authors' abstract of an article published in European Journal of Immunology, "Genetically modifying tumor cells to express a variety of cytokines such as interleukin-2 (IL-2) or the co-stimulatory molecule B7.1 leads to increased immunogenicity and reduced tumorigenicity of tumors in several models with T cells involved in the process. We have previously reported decreased tumorigenicity of the murine plasmacytoma J558L [major histocompatibility complex (MHC) class I+ and class II-] expressing IL-2 or B7.1. When systemic immunity was analyzed, immunization with either J558-IL2 or J558-B7.1 cells generated moderate protection against unmodified J558L...
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Source: Vaccine Weekly (1997-09-08)
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