Cancer Gene Therapy
Costimulatory Molecules CD80 and CD86 Augment Tumor Immunogenicity
Published in Vaccine Weekly, September 8th, 1997
CD80 (B7-1) and CD86 (B7-2) are co-stimulatory molecules, which when transfected onto tumor cells, represent a means of augmenting the immunogenicity of the tumor cells to induce a host immune response directed against the tumor antigens.
In previous research, German researchers Wolfgang Rudy and colleagues demonstrated that this immune response was not always sufficient enough to induce T-cell proliferation (A. Habicht and W. Rudy et al., Eur. J. Cancer, 1995;31A:2396).
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Source: Vaccine Weekly (1997-09-08)
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