"Measurement of TCRBV Subfamily and T Cell Clonotype Frequencies in Heterogeneous lymphocyte Populations."

According to an abstract submitted by the authors to the 88th Annual Meeting of the American Association for Cancer Research, held April 12-16, 1997, in San Diego, California, "The identification of melanoma associated antigens has led to new treatment strategies for patients with metastatic melanoma. Methods currently being used to evaluate vaccine efficacy include measuring antigen specific T cell proliferation, increases in cytokine release, or increases in cytolytic activity following treatment. As an alternative, we have developed a rapid, sensitive, and reproducible method for measuring the frequency of antigen specific T cell clones using competitive PCR (cPCR). This method...

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