Parasitology (Plasmodium)

TRAP Is Essential for Sporozoite Gliding Motility

Published in Vaccine Weekly, October 6th, 1997

Thrombospondin-related anonymous protein (TRAP) is critical for malaria sporozoite infection, researchers have demonstrated.

TRAP is a surface protein expressed by Plasmodium sporozoites, noted Ali A. Sultan, New York University Medical Center, and colleagues. The sporozoite is the stage of the parasite that invades salivary glands of the mosquito vector as well as the liver of the vertebrate host.

Sultan et al. disrupted the TRAP gene in P. berghei to study the role of TRAP in the development of sporozoites and their interactions with host cells ("TRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium...

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Source: Vaccine Weekly (1997-10-06)

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