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Transplantation

Oral Vaccine Tested That Prevents Corneal-Transplant Rejection

Published in Vaccine Weekly, October 6th, 1997

Ophthalmologists at the University of Texas Southwestern Medical Center at Dallas, Texas, have developed an oral vaccine that may prevent rejection of corneal transplants, the most common type of tissue transplant.

About 40,000 corneal transplants are performed in the United States each year with a success rate approaching 90 percent; however, UT Southwestern ophthalmologists are conducting research to help the 10 percent who continually reject corneal transplants. The ophthalmologists are perfecting a novel oral vaccine that slowly trains the recipient's immune system to accept donated corneas.

"Even in the face of powerful immunosuppressive...

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