Cancer Vaccines
"Genetic Immunization Against Mutant P53."
Published in Vaccine Weekly, March 23rd, 1998
According to an abstract submitted by the authors to the Gene Therapy of Cancer VI conference, held November 20-22, 1997, in San Diego, California, "The most common genetic alteration in cancer is in the tumor suppressor gene, p53. P53 is a nuclear protein involved in slowing the cell cycle to allow for cellular DNA repair. Defects in p53 lead to additional mutations in other genes and eventual malignant transformation. Thus, mutated p53 is an attractive target for active, specific immunization. We constructed a plasmid containing specific mutations in p53 which encode antigenic peptides corresponding to Balb/c MHC presentation motifs. Mice were immunized...
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Source: Vaccine Weekly (1998-03-23)
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