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Meningococcal B Disease

"Human T-Cell Responses After Vaccination with the Norwegian Group B Meningococcal Outer Membrane Vesicle Vaccine."

Published in Vaccine Weekly, April 6th, 1998

According to the authors' abstract of an article published in Infection and Immunity, "We have analyzed human T-cell responses in parallel with serum immunoglobulin G (IgG) antibody levels after systemic vaccination with the Norwegian group B Neisseria meningitidis outer membrane vesicle (OMV) vaccine. Ten adult volunteers, with no or very low levels of serum IgG antibodies against meningococci, received three doses intramuscularly of the OMV vaccine (at weeks 0, 6, and 46). T-cell proliferation against the OMV vaccine, purified outer membrane proteins (PorA and PorB), and control antigens (Mycobacterium bovis BCG vaccine and tetanus toxoid) was measured by thymidine...

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