"Bone Marrow-Derived Dendritic Cells Can Induce HBV Envelope-Specific Cytotoxic T Lymphocytes in HBV Transgenic Mice."

According to an abstract submitted by the authors to the 19th US-Japan Hepatitis Joint Panel Meeting, held January 27-29, 1998, at the Asilomar Conference Center in Pacific Grove, California, "Bone marrow-derived dendritic cells (DCs) express high levels of costimulatory molecules and are potent inducers of antigen-specific T cell responses in vitro and in vivo. In this study we injected HBsAg-loaded DCs into 3 independent lineages of HBV transgenic (Tg) mice which are tolerant to HBsAg at the T cell level, in order to determine whether activated DCs can break tolerance and induce antigen-specific CTL in these animals. Control Tg animals were immunized with a plasmid containing the...

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