Conference Coverage (Palm Springs Symposium)

Antibody Maturation: Key Correlate of AIDS Immunity?

Published in Vaccine Weekly, April 6th, 1998

The answer to a single question may hold the key to an AIDS vaccine: why does it take six to 10 months for monkeys inoculated with attenuated live simian immunodeficiency virus (SIV) vaccines to develop protective immunity'

Comparison of the immune responses of various mammals and humans to lentivirus infection reveals that the maturation of antibody responses is a common theme in protection against disease. Immature antibody responses are associated with disease progression.

The findings come with a promise and a warning. The promise is that there may be a way to elicit mature anti-HIV immunity. The warning is that suboptimal HIV vaccines may...

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Source: Vaccine Weekly (1998-04-06)

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