HIV Vaccines
"Evaluation of a Candidate Human Immunodeficiency Virus Type 1 (HIV 1) Vaccine in Macaques: Effect of Vaccination with HIV-1 gp120 on Subsequent Challenge With Heterologous Simian Immunodeficiency Viru
Published in Vaccine Weekly, April 27th, 1998
According to the authors' abstract of an article published in Journal of General Virology, "Human immunodeficiency virus type 1 (HIV-1) envelope vaccines can now be evaluated for efficacy in macaques by challenging with chimeric viruses in which the env, tot and rev genes of simian immunodeficiency virus (SIV) have been replaced by those of HIV-1. Most experiments have so far been conducted using gp120 molecules derived from T-cell-adapted LAI or MN strains of HIV-1, which predominantly use the CXCR-4 co-receptor. These vaccines protect against infection by apathogenic chimeric virus carrying the same envelope sequences. In the experiment described here, four...
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Source: Vaccine Weekly (1998-04-27)
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