"Apoptosis in Asymptomatic HIV-1 Seropositives Immunized With HIV-1 env Glycoprotein (gp160): Effects of Administration of Zidovudine in vivo and Interleukin-2 in vitro."

According to the authors' abstract of an article published in Vaccine, "In this paper we report the effects of VaxSyn^R (Protein Sciences Corp.) immunization on spontaneous apoptosis occurring in vitro after culture of PBMC in medium alone in 30 HIV seropositive patients enrolled in a double-blind clinical trial that included three groups: treatment with VaxSyn, AZT and VaxSyn, and AZT. Our data show no significant modifications in the levels of apoptosis observed in the three groups over the long-term follow-up (up to 720 days). This was not associated with any significant modifications in other clinical or immunological features. However, analysis of apoptosis performed...

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