Leishmaniasis (Vaccines)
"Genetic Control of Immune Response to Recombinant Antigens Carried by an Attenuated Salmonella typhimurium Vaccine Strain: Nramp1 Influences T-helper Subset Responses and Protection Against Leishma
Published in Vaccine Weekly, June 22nd, 1998
According to the authors' abstract of an article published in Infection and Immunity, "Attenuated stains of Salmonella typhimurium have been widely used as vehicles for delivery and expression of vaccine antigens in murine models of infectious disease. In mice, early bacterial replication following infection with S. typhimurium is controlled by the gene Nramp1 (formerly Ity/Lsh/Bcg) encoding the natural-resistance-associated macrophage protein Nramp1. Nramp1 regulates macrophage activation and has multiple pleiotropic effects, including regulation of tumor necrosis factor alpha, interleukin 1 beta (IL-1 beta), and major histocompatibility complex class PI molecules, all of...
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Source: Vaccine Weekly (1998-06-22)
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