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Vaccine Development (TB)

Listeriolysin-Secreting BCG May Make Better Vaccine

Published in Vaccine Weekly, June 22nd, 1998

Recombinant bacillus Calmette-Guerin constructs that secrete a cytolysin essential for the release of Listeria monocytogenes may hold the key to an improved tuberculosis vaccine.

Researchers from Germany's Max-Planck Institute for Infection Biology found that certain antigens with the pore-forming sulfhydryl-activated cytolysin Hly may enhance CD8 T cell stimulation.

Bacillus Calmette-Guerin (BCG), the only vaccine available for the prevention of tuberculosis, has shown an efficacy ranging from 0 percent to 80 percent in field trials.

"BCG should be improved, e.g., by genetic engineering to provide a vaccine for better TB...

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