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Haemophilus influenzae

"Economisation of Vaccination Against Haemophilus influenzae Type b: A Randomised Trial of Immunoaffinity of Fractional-Dose and Two-Dose Regimens."

Published in Vaccine Weekly, July 13th, 1998

According to the authors' abstract of an article published in Lancet, "Background: The cost of Haemophilus influenzae type b (Hib) conjugate vaccines has limited their use in non-industrialised countries. To identify more economical vaccination schedules, we carried out a randomised trial of the immunogenicity of alternative regimens to the standard three-dose series. Methods: 627 Chilean infants were randomly allocated to one of four regimens with either Hib polysaccharide-tetanus toxoid conjugate vaccine (PRP-T) or Hib oligosaccharide-diphtheria mutant toxoid conjugate vaccine (PRP-CRM197), for a total of eight groups. All infants receive...

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