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Cancer Vaccines

Melanoma DNA Vaccine Trial Initiated

Published in Vaccine Weekly, August 10th, 1998

Vical Inc., San Diego, California, announced the initiation of a Phase I/II clinical trial to study the safety and potential efficacy of an experimental DNA vaccine for patients with metastatic melanoma.

The trial is being sponsored by the U.S. National Cancer Institute (NCI) under the direction of Steven A. Rosenberg, M.D., Ph.D., Chief of Surgery.

The experimental vaccine contains a gene which may cause cells at the injection site to produce a modified gp100 melanoma antigen. The antigen is expected to trigger an immune response against melanoma tumor cells. In earlier studies, Rosenberg tested a vaccine using peptides (portions of the modified...

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