Conference Coverage (12th World AIDS)

HIV Tat Selects Infecting Viral Variant

Published in Vaccine Weekly, August 10th, 1998

HIV-1 has yet another amazing trick up its sleeve: its Tat protein can inhibit some strains of HIV.

This seeming contradiction provides an answer to the long-standing question of exactly why, when a transmitting individual carries both T-cell-tropic (T-tropic) and macrophage-tropic (M-tropic) HIV strains, only the M-tropic virus is transmitted.

"There really are two effects of Tat," said Kuan-Teh Jeang of the National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. "At low concentrations, there is blocking of infectivity. At high concentrations, increased transactivation overrides this inhibition. But that only happens...

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Source: Vaccine Weekly (1998-08-10)

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