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Immunology

Attenuated Recombinant B. Pertussis Enhances Protection against Parasites

Published in Vaccine Weekly, August 10th, 1998

Attenuated recombinant Bordetella pertussis strains may be suitable vectors for disease protection through one intranasal administration.

Although single-dose mucosal immunization is best achieved by using attenuated live microorganisms, such attenuation usually results in decreased immunogenicity.

N. Mielcarek and colleagues attenuated Bordetella pertussis by deleting the pertussis toxin gene ("Homologous and Heterologous Protection after Single Intranasal Administration of Live Attenuated Recombinant Bordetella pertussis," Nature Biotechnology, May 1998;16(5):454-457).

"A single intranasal administration of...

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