Published in Vaccine Weekly, August 10th, 1998
Although single-dose mucosal immunization is best achieved by using attenuated live microorganisms, such attenuation usually results in decreased immunogenicity.
N. Mielcarek and colleagues attenuated Bordetella pertussis by deleting the pertussis toxin gene ("Homologous and Heterologous Protection after Single Intranasal Administration of Live Attenuated Recombinant Bordetella pertussis," Nature Biotechnology, May 1998;16(5):454-457).
"A single intranasal administration of...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
Source: Vaccine Weekly (1998-08-10)
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.