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Vaccine Development

 Salmonella Bacterium Used as Vaccine Delivery System

Published in Vaccine Weekly, September 7th, 1998

The success of any global vaccination program depends on a vaccine that is stable, easy to administer, and effective at stimulating complex immune responses.

Toward this end, researchers are experimenting with live, replicating bacteria and viruses that have been stripped of their virulence and rigged to express foreign proteins that, in a natural state, would cause disease but in the vaccine will only stimulate immunity.

H. Russman and colleagues at the University of Nebraska and the State University of New York at Stony Brook reported on their efforts to make Salmonella, a bacterium that normally causes food poisoning, an effective delivery...

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