Published in Vaccine Weekly, September 7th, 1998
Researchers Rigmor Thorstensson and colleagues expected to find that vaccines capable of protecting monkeys against intrarectal challenge with pathogenic simian immunodeficiency virus (SIV) would stimulate beta chemokine production.
The beta chemokines (RANTES, MIP-1(alpha), and MIP-1(beta)) are the natural ligands for the CCR5 receptor used for cell entry by the great majority of infectious HIV strain. High beta-chemokine levels are associated with protection against HIV infection and disease.
But they obtained...
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