Conference Coverage (12th World AIDS)

New HIV Trick: Immunization Against Antiviral Chemokines

Published in Vaccine Weekly, September 7th, 1998

HIV has yet another pernicious trick: it vaccinates against antiviral defenses.

New data suggest that epitopes carried in the V3 loop of the HIV-1 envelope elicit antibodies. These antibodies don't seem to hurt HIV: but they attack and immobilize beta chemokines, the body's first-line defense against HIV infection.

"Our data indicate that anti-chemokine activities in the sera of HIV⁺ patients are due to a cross-reaction of anti-V3-loop antibodies with chemokines," noted Caner Susal and colleagues of the University of Heidelberg, Germany.

Susal reported the findings at the 12th World AIDS Conference, held June 28-July...

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Source: Vaccine Weekly (1998-09-07)

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