Animal Models (TB)

Prior BCG Vaccine Alters Response to hsp 65 and hsp 70

Published in Vaccine Weekly, September 7th, 1998

Animal studies suggest that heat shock protein 65 is not protective against active tuberculosis.

Researchers found that prior vaccination with bacillus Calmette-Guerin boosted cellular immune response to purified protein derivative and heat shock protein 70 in mycobacteria-challenged guinea pigs, but the T cell response to heat shock protein 65 was not boosted.

"We believe that these data are inconsistent with a protective role for the heat shock protein (hsp) 65 in this model," R.A. Bartow and D.N. McMurray of the Texas A&M University Health Science Center wrote ("Cellular and Humoral Immune Responses to Mycobacterial Stress Proteins in Experimental...

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Source: Vaccine Weekly (1998-09-07)

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