"Partially Protective Vaccination Permits the Development of Latency in a Normally Virulent Strain of Toxoplasma gondii."

According to the authors' abstract of an article published in Infection and Immunity, "The virulent RH strain of Toxoplasma gondii is acutely lethal in mice and fails to establish chronic infection. Vaccination of BALB/c mice with a soluble tachyzoite antigen preparation, STAg, in combination with the immunostimulatory cytokine interleukin-12 results in partial protection against RH lethal challenge. Nevertheless, brain tissue obtained from surviving, vaccinated mice as late as 1 year after RH infection contained latent parasite forms as demonstrated by subinoculation into naive recipients. The tachyzoites arising in the subinoculated animals were genetically indistinguishable...

Want to see the full article?

• Purchase this article for only $3.00