Cancer Vaccines
"MAGE, BAGE and GAGE: Tumour Antigen Expression in Benign and Malignant Ovarian Tissue."
Published in Vaccine Weekly, October 19th, 1998
According to the authors' abstract of an article published in British Journal of Cancer, "To determine if ovarian cancer patients would be suitable for MAGE-peptide vaccine-based immunotherapy, the frequency of expression of the MAGE-1-4 genes in ovarian tumours was assessed using reverse transcription polymerase chain reaction (RT-PCR) and product verification with digoxigenin-labelled oligonucleotide probes specific for each MAGE gene. In addition, the frequency of expression of more recently discovered tumour antigens (BAGE, GAGE -1, -2 and GAGE -3, -6) was established using RT-PCR and ethidium bromide staining. In this study, 1/16 normal ovarian tissue specimens and 11/25 benign...
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Source: Vaccine Weekly (1998-10-19)
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