Peptide Immunization
"IFN-gamma-Secreting T-h Cells Regulate Both the Frequency and Avidity of Epitope-Specific CD8+ T Lymphocytes Induced by Peptide Immunization: An ex vivo Analysi
Published in Vaccine Weekly, October 26th, 1998
According to the authors' abstract of an article published in International Immunology, "CD8+ T lymphocytes are involved in protective immune responses to infected or tumor cells. In this report, we examined the regulation of antigen-specific CD8+ T-cell frequency and avidity by distinct T-h cell subsets. Peptide-specific CD8+ T cells were induced by immunization of mice with a MHC class I-restricted epitope, co-injected with a MHC class II-restricted epitope to recruit T-h cells. CD8+ T-cell responses were assessed directly ex vivo for lytic activity and IFN-gamma secretion using the enzyme-linked immunospot (ELISPOT) assay. Co-immunization...
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Source: Vaccine Weekly (1998-10-26)
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