Schistosomiasis
"In the Absence of IL-12, the Induction of Th1-Mediated Protective Immunity by the Attenuated Schistosome Vaccine Is Impaired, Revealing an Alternative Pathway with Th2-Type Characteristics. DOUB
Published in Vaccine Weekly, October 26th, 1998
According to the authors' abstract of an article published in European Journal of Immunology, "Vaccination of mice with irradiated Schistosoma mansoni larvae confers high levels of immunity which is mediated by Th1-type lymphocytes. To investigate a possible role for IL-12 in the induction of protection, we have compared the immune response of IL-12 p40-deficient (KO) mice and their C57BL/6 (WT) counterparts following vaccination. Cultured lymph node cells from KO mice had markedly altered cytokine profiles with significantly decreased production of IFN-gamma increased IL-4. Correspondingly, KO mice had enhanced levels of IgE. After challenge, cells recovered from the lungs of...
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Source: Vaccine Weekly (1998-10-26)
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