Published in Vaccine Weekly, October 26th, 1998
Using the murine parasite Plasmodium yoelii (Py) as a model for the development of a malaria vaccine, U.S. Naval Medical Research Institute researchers previously demonstrated that a DNA plasmid encoding the Py circumsporozoite protein (PyCSP) can protect mice against sporozoite infection (Sedegah et al., Proc Natl Acad Sci USA, 1994;91:9866).
The research team has continued to search for ways to enhance the effectiveness of DNA vaccines.
"We now report that mixing a new plasmid PyCSP##1012## with a plasmid encoding murine granulocyte-macrophage...
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