Polysaccharide Vaccines
"Antigenic Determinants of Staphylococcus aureus Type 5 and Type 8 Capsular Polysaccharide Vaccines."
Published in Vaccine Weekly, November 9th, 1998
According to the authors' abstract of an article published in Infection and Immunity, "Bacterial capsular polysaccharides (CP) are carbohydrate polymers [composed] of repeating saccharide units. Several of these CP have side chains attached to their backbone structures. The side chains may include O-acetyl, phosphate, sialic acid, and other moieties. Those moieties represent the immunodominant epitopes and the most functional ones. The clinically significant Staphylococcus aureus type 5 CP (CP 5) and type 8 CP (CP 8) comprise a trisaccharide repeat unit with one O-acetyl group attached to each repeat unit. The immunogenicity of these CP and the functionality of antibodies to...
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Source: Vaccine Weekly (1998-11-09)
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