"Evaluation of Humoral and Cellular Immune Responses Following DNA Immunization and Challenge of Guinea Pigs With Ebola Virus."

According to an abstract submitted by the authors to the 47th Annual Meeting of the American Society of Tropical Medicine and Hygiene, that was to have been held October 18-22, 1998, in San Juan, Puerto Rico, "Three immunizations of guinea pigs with 100 mg GP-DNA 2 weeks apart results in >80% protection from challenge with a >1000 LD₅₀ dose of Ebola virus (EV). We investigated the relationship between humoral and cellular immune responses to EV glycoproteins following DNA immunization with a plasmid encoding the structural glycoprotein (GP) of a guinea pig-adapted human EV isolate. Serum IgG anti-GP titers were >400 in 100% of GP-vaccinated (GPV) and 0% of control...

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